PIR介导先天髓样细胞对非自身MHC分子的记忆

美国匹兹堡大学Fadi G. Lakkis、Martin H. Oberbarnscheidt、康奈尔大学Xian C. Li等研究人员合作发现，PIR介导先天髓样细胞对非自身MHC分子的记忆。该研究于2020年5月7日在线发表于《科学》。

研究人员表明，鼠单核细胞和巨噬细胞获得MHC-I抗原特有的记忆，并识别成对的免疫球蛋白样受体-A（PIR-A）作为记忆应答所必需的MHC-I受体。

研究人员证明敲除受体中的PIR-A或阻止PIR-A与供体MHC-1分子的结合会阻止记忆并减弱肾脏和心脏同种异体移植的排斥反应。因此，先天髓样细胞获得了同种异体抗原特异性记忆，这可用于改善移植效果。

据了解，免疫记忆是适应性淋巴样细胞的主要特征，这种记忆特定于先前遇到的抗原。然而，尚不清楚先天髓样细胞是否保留先前抗原刺激的记忆，并在随后的相遇中对其产生更强烈的反应。

附：英文原文

Title: PIRs mediate innate myeloid cell memory to nonself MHC molecules

Author: Hehua Dai, Peixiang Lan, Daqiang Zhao, Khodor Abou-Daya, Wentao Liu, Wenhao Chen, Andrew J. Friday, Amanda L. Williams, Tao Sun, Jianjiao Chen, Wei Chen, Steven Mortin-Toth, Jayne S. Danska, Chris Wiebe, Peter Nickerson, Tengfang Li, Lisa R. Mathews, Hêth R. Turnquist, Matthew L. Nicotra, Sebastien Gingras, Eiji Takayama, Hiromi Kubagawa, Mark J. Shlomchik, Martin H. Oberbarnscheidt, Xian C. Li, Fadi G. Lakkis

Issue&Volume: 2020/05/07

Abstract: Abstract Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. It is unknown however whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously upon subsequent encounters. Here, we show that murine monocytes and macrophages acquire memory specific to MHC-I antigens and identify paired immunoglobulin-like receptors-A (PIR-A) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.

DOI: 10.1126/science.aax4040

Source: https://science.sciencemag.org/content/early/2020/05/06/science.aax4040

转载自：http://news.sciencenet.cn/htmlpaper/2020/5/202051012461789256312.shtm